Basic and Clinical Neuroscience Journal

en A Review of Immune and Histological Brain Changes Following Early Life Adversity Cognitive Neuroscience Cognitive Neuroscience Review Review <div style="text-align: justify;">Exposure to stressors in early life is an important factor in shaping an individual's health in later stages of life.  Besides, the growing range of stressors during the very first 1000 day of human life may lead to critical biophysiological consequences. The results of previous studies have shown that ELA contact to a stressor reduces the capacity of the immune system to produce subsequent generations of naive cells, as well as, the capacity of neuronal stem cells to proliferate. In today's modem societies, stressors and their later-life outcomes have significantly increased, yet the molecular mechanisms behind them are still not well understood. Due to the above reasons, animal models of postnatal stress have been widely developed. Since in the first days of life, a reciprocal relationship between the mother and baby is needed for proper growth and development, disruption of this relationship may lead to permanent changes in neurobiology and neurobehavioral mechanisms of individuals.</div> Astrocytes, Cognition, Early life adversity (ELA), Early life Stress (ELS), Maternal separation (MS) 0 0 http://bcn.iums.ac.ir/browse.php?a_code=A-10-8387-1&slc_lang=en&sid=1 parisa salehi najafabadi Salehi.p.262@gmail.com 13700319475328460058416 13700319475328460058416 No Kerman University of Medical Sciences, Kerman, Iran Moein Salari s.moein17@gmail.com 13700319475328460058417 13700319475328460058417 No Sirjan School of Medical Sciences, Kerman, Iran Sara Joushi s.joushi@kmu.ac.ir 13700319475328460058418 13700319475328460058418 No Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Mohsen Basiri basirimohsen@gmail.com 13700319475328460058419 13700319475328460058419 Yes Kerman University of Medical Sciences, Kerman, Iran