دوره 14، شماره 2 - ( 12-1401 )                   جلد 14 شماره 2 صفحات 272-263 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nematollahi-Mahani S N, Ganjalikhan-Hakemi S, Abdi Z. The Regression of Glioblastoma Multiforme is Time Dependent in the Wild-type Rat Xenograft Model. BCN 2023; 14 (2) :263-272
URL: http://bcn.iums.ac.ir/article-1-2157-fa.html
The Regression of Glioblastoma Multiforme is Time Dependent in the Wild-type Rat Xenograft Model. مجله علوم اعصاب پایه و بالینی. 1401; 14 (2) :263-272

URL: http://bcn.iums.ac.ir/article-1-2157-fa.html


چکیده:  
Introduction: Glioblastoma multiforme (GBM) is an aggressive case of primary brain cancer which remains among the most fatal tumors worldwide. Although, some in vitro and in vivo models have been developed for a better understanding of GBM behavior; a natural model of GBM would improve the efficiency of experimental models of human GBM tumors. We aimed the present study to examine the survival and durability of U87 cells in the brain of wild-type rats.
Methods: U87 cells were intracranially implanted in twenty-one wild-type rats. Tumor size and morphology as well as infiltration of immune cells were investigated at three-time points by H&E and immunohistochemistry (IHC).
Results: The results demonstrated that the inoculation of GBM cells led to the infiltration of host defense system cells which caused immunological regression of the tumor mass after six weeks. While the tumors successfully developed without any sign of host defense invasion in the second week of GBM inoculation. Also, a decrease in tumor size and infiltration of immune system cells were observed in the fourth week.
Conclusion: These data remarkably suggest that time plays a crucial role in activating the immune system against human GBM tumors in rats; it shows that the regression of tumor mass depends on a time slope.
نوع مطالعه: Original | موضوع مقاله: Cellular and molecular Neuroscience
دریافت: 1400/2/11 | پذیرش: 1400/6/15 | انتشار: 1401/12/10

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Basic and Clinical Neuroscience می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb