Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1397
8
1
gregorian
2018
11
1
9
6
online
1
fulltext
en
Sleep Architecture and Hypothalamic-Pituitary-Adrenal Activity in Paradoxical and Psychophysiological Insomnia
Cognitive Neuroscience
Cognitive Neuroscience
Original
Original
<p style="text-align: justify;"><strong>Introduction: </strong>There are controversial reports about association between sleep and Hypothalamic-Pituitary-Adrenal (HPA) activity. Studies have reported the influence of insomnia on HPA hormones. However, they usually ignored the heterogeneity of insomnia symptoms, so subtypes of the disorder have not been considered in the reports. The present study aimed to investigate the final and intermediate products of HPA system among a group of psychophysiological and paradoxical insomniac patients in comparison to a group of normal sleepers. <br>
<strong>Methods: </strong>We investigated the awakening serum level of Adrenocorticotropic Hormone (ACTH) and cortisol after one night Polysomnography (PSG) in 17 subjects with psychophysiological insomnia, 19 subjects with paradoxical insomnia and 17 subjects with normal sleep profile. Groups were matched for age and Body Mass Index (BMI). Serum levels of ACTH and cortisol were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. <br>
<strong>Results:</strong> Although, a tendency toward elevation of both ACTH and cortisol was observed among patients with paradoxical insomnia compared to both control and psychophysiological insomnia, the differences were not significant comparing three groups. According to regression analysis, higher Non-Rapid Eye Movement sleep (NREM) arousal and Pulse Transit Time (PTT) significantly predicted higher level of ACTH. <br>
<strong>Conclusion:</strong> These findings could suggest the personality traits hypothesis for paradoxical insomnia. Both cortical and subcortical arousal could lead to more HPA activity and higher ACTH level. Further studies are recommended to confirm the hypothesis. </p>
Cortisol, Adrenocorticotropic Hormone (ACTH), Sleep disorder, Insomnia
397
407
http://bcn.iums.ac.ir/browse.php?a_code=A-10-664-3&slc_lang=en&sid=1
Hiwa
Mohammadi
hiwa.mohamadi@gmail.com
13700319475328460018897
13700319475328460018897
No
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Neurology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad
Rezaei
mohammad.rezaei@kums.ac.ir
13700319475328460018898
13700319475328460018898
No
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Seyed Mojtaba
Amiri
sm.amiri@yahoo.com
13700319475328460018899
13700319475328460018899
No
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Zohreh
Rahimi
rahimizus@yahoo.com
13700319475328460018900
13700319475328460018900
No
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Kamran
Mansouri
kmansouri@kums.ac.ir
13700319475328460018901
13700319475328460018901
No
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Habibolah
Khazaie
hakhazaie@gmail.com
13700319475328460018902
13700319475328460018902
Yes
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.