Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1397
4
1
gregorian
2018
7
1
9
4
online
1
fulltext
en
The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction:</strong> According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI).<br>
<strong>Methods:</strong> Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i.p. 5 mg/kg), and CCI+rosuvastatin (i.p. 10 mg/kg). We performed heat hyperalgesia, cold and mechanical allodynia tests on the 3rd, 7th, 14th, and 21st after inducing CCI. Blood samples were collected to measure the serum levels of Tumor Necrosis Factor (TNF)-α, and Interleukin (IL)-6. Rats’ spinal cords were also examined to measure tissue concentration of Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) enzymes. <br>
<strong>Results:</strong> Our findings showed that CCI resulted in significant increase in heat hyperalgesia, cold and mechanical allodynia on the 7th, 14th and 21st day. Rosuvastatin use attenuated the CCI-induced hyperalgesia and allodynia. Rosuvastatin use also resulted in reduction of TNF-α, IL-6, and MDA levels. However, rosuvastatin therapy increased the concentration of SOD and GPx in the CCI+Ros (5 mg/kg) and the CCI+Ros (10 mg/kg) groups compared to the CCI group. <br>
<strong>Conclusion:</strong> Rosuvastatin attenuated the CCI-induced neuropathic pain and inflammation. Thus, antinociceptive effects of rosuvastatin might be channeled through inhibition of inflammatory biomarkers and antioxidant properties.</div>
Rosuvastatin, Neuralgia, Chronic Constriction Injury (CCI), Rats
251
260
http://bcn.iums.ac.ir/browse.php?a_code=A-10-895-1&slc_lang=en&sid=1
Amin
Hasanvand
dr.hasanvand@yahoo.com
13700319475328460016359
13700319475328460016359
Yes
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
Fariba
Ahmadizar
F.Ahmadizar@uu.nl
13700319475328460016360
13700319475328460016360
No
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Abolfazl
Abbaszadeh
daa200028@gmail.com
13700319475328460016361
13700319475328460016361
No
Department of Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Hossein
Amini-Khoei
aminikhoyi@gmail.com
13700319475328460016362
13700319475328460016362
No
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Mehdi
Goudarzi
goudarzi787@gmail.com
13700319475328460016363
13700319475328460016363
No
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Amir
Abbasnezhad
abbasnezhad91@gmail.com
13700319475328460016364
13700319475328460016364
No
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Razieh
Choghakhori
razieh_choghakhori@yahoo.com
13700319475328460016365
13700319475328460016365
No
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.