Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1395
7
1
gregorian
2016
10
1
7
4
online
1
fulltext
fa
Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p style="text-align: justify;">The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system.</p>
Nitric oxide, Opioid, Amygdala, Ventral tegmental area, Nucleus accumbens
283
290
http://bcn.iums.ac.ir/browse.php?a_code=A-10-992-2&slc_lang=fa&sid=1
Amir
Arash Motahari
1370031947532846008537
1370031947532846008537
No
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hedayat
Sahraei
1370031947532846008538
1370031947532846008538
No
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Gholam Hossein
Meftahi
meftahi208@yahoo.com
1370031947532846008539
1370031947532846008539
Yes
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.