Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
6
1
gregorian
2017
9
1
8
5
online
1
fulltext
en
Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p style="text-align: justify;"><strong>Introduction:</strong> Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrogen genistein on seizure-induced cognitive and synaptic plasticity impairment in Ovariectomized (OVX) rats.<br>
<strong>Methods:</strong> Rats were ovariectomized, implanted with guide cannula and then divided into 5 groups (n=7-8 in each group): PBS, KA, Saline-KA, Higher Dose Soy (HDS-KA), and Lower Dose Soy (LDS-KA) groups. Animals of the HDS-KA and LDS-KA groups received intraperitoneal administration of soy extract (20 and 2 mg/kg, respectively) and the Saline-KA group received normal saline once a day for 4 days. Sixty minutes after the last injection, Kainic Acid (KA) or PBS was injected into the left lateral ventricle via pre-implanted guide cannula to induce generalized seizures. The Morris water maze task and in vivo field potential recordings were conducted 7 days later.<br>
<strong>Results:</strong> Soy extract at both doses significantly improved learning impairment and at the higher dose (20 mg/kg) significantly prevented seizure-induced spatial memory impairment and deficit of long-term potentiation in the hippocampus.<br>
<strong>Conclusion:</strong> The soy extract containing the phytoestrogen genistein may have beneficial effects on memory deficit induced by seizure in OVX rats and this effect is accompanied by a beneficial effect on synaptic plasticity.</p>
Seizure, Soy extract, Genistein, Long-term potentiation, Spatial memory
395
404
http://bcn.iums.ac.ir/browse.php?a_code=A-10-992-1&slc_lang=en&sid=1
Mehdi
Khodamoradi
mehdikhodamoradi98@gmail.com
13700319475328460010942
13700319475328460010942
No
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Majid
Asadi-Shekaari
13700319475328460010943
13700319475328460010943
No
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Saeed
Esmaeili-Mahani
13700319475328460010944
13700319475328460010944
No
Department of Biology, Faculty of Science, Shahid Bahonar University, Kerman, Iran.
Fariba
Sharififar
13700319475328460010945
13700319475328460010945
No
Herbal and Traditional Medicines Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Vahid
Sheibani
v_sheibani@kmu.ac.ir
13700319475328460010946
13700319475328460010946
Yes
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.