Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
4
1
gregorian
2017
7
1
8
4
online
1
fulltext
en
A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p style="text-align: justify;"><strong>Introduction:</strong> Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus.<br>
<strong>Case Presentation: </strong>A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy.<br>
<strong>Conclusion:</strong> Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures.</p>
Mitochondrial disorder, MELAS Syndrome, Middle age
337
343
http://bcn.iums.ac.ir/browse.php?a_code=A-10-862-1&slc_lang=en&sid=1
Mostafa
Almasi
a_mostafa108@yahoo.com
13700319475328460010920
13700319475328460010920
Yes
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Reza
Motamed
Mrmotamed2005@yahoo.com
13700319475328460010921
13700319475328460010921
No
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Masoud
Mehrpour
mehrpr@yahoo.com
13700319475328460010922
13700319475328460010922
No
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bahram
Haghi-Ashtiani
Bhaghi2000@yahoo.com
13700319475328460010923
13700319475328460010923
No
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Fahimeh
Haji Akhondi
fhakhoundi@yahoo.com
13700319475328460010924
13700319475328460010924
No
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Yalda
Nilipour
yalnil@yahoo.com
13700319475328460010925
13700319475328460010925
No
Pediatric Pathology Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed-Mohammad
Fereshtehnejad
sm.fereshtehnejad@ki.se
13700319475328460010926
13700319475328460010926
No
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.