Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1395
12
1
gregorian
2017
3
1
8
2
online
1
fulltext
en
The Effect of Luteinizing Hormone Reducing Agent on Anxiety and Novel Object Recognition Memory in Gonadectomized Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p style="text-align: justify;"><strong><span dir="LTR">Introduction</span></strong><span dir="LTR">: Mood disorders such as anxiety and depression are common following menopause and andropause. The lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are not clear yet. This study aimed to investigate the effect of increased LH on novel object discrimination (NOD) memory and anxiety like behavior in gonadectomized rats.</span></p>
<p style="text-align: justify;"><strong><span dir="LTR">Methods:</span></strong><span dir="LTR"> Four-month-old male and female Wistar rats were randomly assigned into 4 groups (in each sex): Control rats (Cont), gonadectomized without treatment (GnX), gonadectomized treated with triptorelin (a GnRH agonist which decreases LH release) (GnX+Tr), gonadectomized treated with triptorelin plus sex steroid hormone, estradiol in female and testosterone in male rats (GnX+Tr+S/T). After 4 weeks treatment, anxiety score (elevated plus maze) and NOD were measured. Data were analyzed using 1- way ANOVA, and P values less than 0.05 were considered as significant.</span></p>
<p style="text-align: justify;"><strong><span dir="LTR">Results</span></strong><span dir="LTR">: Gonadectomy increased anxiety like behaviors (decrease of presence time in the open arms) in female rats (P=0.012), but not in male ones (P = 0.662). Additionally, triptorelin alone reduced the increased anxiety score in gonadectomized female rats, compared to group treated with both triptorelin and estradiol. Furthermore, it was shown that gonadectomy and or treatment with triptorelin and sex steroids had no significant effect on the new object recognition memory in both female (P = 0.472) and male rats (P = 0.798). </span></p>
<p dir="ltr" style="text-align: justify;"><strong>Conclusion</strong>: On the whole, this study revealed that increased level of LH following menopause or andropause should be considered as a possible cause for increased anxiety. Also, this study showed that LH reducing agents would reduce anxiety behavior in gonadectomized female rats. The effect of increased LH on cognitive functions such as new object recognition memory was not evident in this study needs further studies and should be interpreted with caution.</p>
Menopause, Andropause, Luteinizing hormone, Gonadectomy, Anxiety, New object recognition memory
113
120
http://bcn.iums.ac.ir/browse.php?a_code=A-10-43-2&slc_lang=en&sid=1
Paria
Arfa-Fatollahkhani
1370031947532846009806
1370031947532846009806
No
Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Arezo
Nahavandi
1370031947532846009807
1370031947532846009807
No
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Hossein
Abtahi
1370031947532846009808
1370031947532846009808
No
Department of Biochemistry and Nutrition, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Shabnam
Anjidani
1370031947532846009809
1370031947532846009809
No
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sahar
Borhani
1370031947532846009810
1370031947532846009810
No
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Seyed Behnam
Jameie
1370031947532846009811
1370031947532846009811
No
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohammad
Shabani
1370031947532846009812
1370031947532846009812
No
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Saeed
Mehrzadi
1370031947532846009813
1370031947532846009813
No
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ali
Shahbazi
1370031947532846009814
1370031947532846009814
Yes
Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.