Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1395
10
1
gregorian
2017
1
1
8
1
online
1
fulltext
en
Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p style="text-align: justify;"><strong>Introduction: </strong>Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin.<br>
<strong>Methods:</strong> In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of the hin limb in adult rats.<br>
<strong>Results:</strong> A typical biphasic nociceptive response was seen after formalin injection into the plantar surface of the hind paw. A brief interphase separates the first and second phases where nociceptive behaviors were barely spotted. However, following subcutaneous injection into the hairy skin nociceptive behaviors were only seen after 10 minutes of formalin injection, which correlates in time with the second phase of the formalin response. First phase nociceptive behaviors were<br>
never seen with hairy skin injection, even following multiple injections of formalin.</p>
<p style="text-align: justify;"><strong>Conclusion:</strong> These data suggest that nociceptive behaviors and spinal responses induced by formalin injections to glabrous and hairy skin areas are different, and that the first and second phases may be mediated through different noxious afferent fibers.</p>
Formalin test, Hairy skin, Glabrous skin, Tonic pain, Nociception
37
42
http://bcn.iums.ac.ir/browse.php?a_code=A-10-257-9&slc_lang=en&sid=1
Elaheh
Erami
13700319475328460010006
13700319475328460010006
No
Department of Nursing, Faculty of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Hassan
Azhdari-Zarmehri
azhdarih1@thums.ac.ir
13700319475328460010007
13700319475328460010007
Yes
Department of Medical Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Keiji
Imoto
13700319475328460010008
13700319475328460010008
No
Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Hidemasa
Furue
13700319475328460010009
13700319475328460010009
No
School of Life Science, University for Advanced studies (SOKENDAI), Okazaki, Japan.