Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1394
1
1
gregorian
2015
4
1
6
2
online
1
fulltext
en
Antiamnesic Effects of Walnuts Consumption on Scopolamine- Induced Memory Impairments in Rats
Cognitive Neuroscience
Cognitive Neuroscience
Original
Original
<b>
Introduction:</b> Alzheimer’s disease (AD) is an age-related neurodegenerative disease, which
impairs memory and cognitive function. Walnuts are a dietary source of polyphenols, antioxidants
and other compounds with health beneficial effects. These characteristic of walnuts make
them perfect candidates for evaluation of their possible effects on neurodegenerative diseases.
Therefore the present study was designed to investigate the effects of walnuts consumption (2%,
6% and 9% walnut diets) on memory enhancement and acetylcholinesterase (AChE) activity of
brain in scopolamine-induced amnesic rats. <div><b>Methods:</b> Learning, memory and locomotor activity parameters were evaluated using Morris
water maze (MWM), passive avoidance and rotarod tests. </div><div><b>Results:</b> Our results showed that consumption of walnuts at doses of 6% and 9% significantly
restored the scopolamine-induced memory impairments in the MWM and passive avoidance
tests. Moreover, the potential of walnuts to prevent scopolamine neurotoxicity was also reflected
by the decreased AChE activity in the whole brain in comparison with the scopolamine group. </div><div><b>Discussion: </b>These results suggest that walnuts may be useful against memory impairment and
it may exert these anti-amnesic activities via inhibition of AChE activity in the brain. It would
be worthwhile to explore the potential of this nut and its active components in the management
of the AD.
</div>
Acetylcholinesterase, Amnesia, Memory, Morris water maze, Passive avoidance, Walnut
91
100
http://bcn.iums.ac.ir/browse.php?a_code=A-10-399-2&slc_lang=en&sid=1
Shaahin
Harandi
shaahin.harandi@gmail.com
1370031947532846005284
1370031947532846005284
No
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Leila
Golchin
leila.golchin@gmail.com
1370031947532846005285
1370031947532846005285
No
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Mehdi
Ansari
1370031947532846005286
1370031947532846005286
No
Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
Alireza
Moradi
1370031947532846005287
1370031947532846005287
No
Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad
Shabani
1370031947532846005288
1370031947532846005288
No
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Vahid
Sheibani
vsheibani2@yahoo.com
1370031947532846005289
1370031947532846005289
Yes
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran