Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1392
11
1
gregorian
2014
2
1
5
1
online
1
fulltext
en
Naloxone Induces Frequent Jumping after Chronic Morphine and Methamphetamine Co-Administration in Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p>Combined use of an opioid with a psychostimulant is popular among drug abusers. Such “polydrug use” may increase drug effects or attenuate adverse effects of either drug alone. We proposed that a combination of methamphetamine (meth) and morphine may change physical opioid withdrawal symptoms. Adult male rats were chronically injected with cumulative subcutaneous (s.c.) doses of morphine, meth or a combination of both drugs within five days. On day six, a challenge dose of the same drug was injected. Two hours later, precipitated withdrawal symptoms were scored within 30 minutes after naloxone (1mg/kg, i.p.) injection. Both frequency and incidence of jumping significantly increased in combined treated animals (P<0.05). The sole emergent symptom in combined treated animals was digging which we consider as another escaping behavior in addition to jumping. Our findings imply that combined use of meth and morphine may exacerbate averseness of morphine withdrawal which may cause more intense opioid dependence</p>
Polydrug Use, Morphine, Meth, Naloxone, Withdrawal Syndrome, Rat
42
47
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-194&slc_lang=en&sid=1
Gholamreza
Kaka
1370031947532846006437
1370031947532846006437
No
Neuroscience Research Center, Baqiyatallah University of Medical Science, Tehran, Iran.
Ramin
Rahmanzade
1370031947532846006438
1370031947532846006438
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farzin
Safee
1370031947532846006439
1370031947532846006439
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abbas
Haghparast
1370031947532846006440
1370031947532846006440
Yes
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.