Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1389
2
1
gregorian
2010
5
1
1
3
online
1
fulltext
en
Electrophysiological Study of Sciatic Nerve Regeneration Through Tubes Seeded with Schwann Cells
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p align="justify"><strong>A B S T R A C T</strong></p><p align="justify"><strong>Introduction:</strong> Peripheral nerve injury is a common disorder and leads to permanent neurological defects. Schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. The aim of this study was to determine the beneficial effect of allograft Schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.</p><p align="justify"><strong>Methods:</strong> Twenty adult male Wistar rats (200-250 g) were used in this study and left sciatic nerve was cut 10 mm in all of them and randomly divided into two groups. Then, the experimental (n=10) and control (n=10) groups received silicon tube with Schwann cells and silicon tube without Schwann cells respectively. Electrophysiological studies were performed 8 weeks after transplantation.</p><p align="justify"><strong> Results:</strong> Electrophysiological study in experimental animals showed that amplitude of nerve action potential is higher and latency is less as compared to the control group (p<0.05).</p><p align="justify"><strong> Discussion:</strong> The combination of different strategies such as silicon tube and Schwann transplantation has a more effective role in nerve repair. </p>
Silicon tube,Schwann cells,Sciatic nerve,Regeneration,Electrophysiology,Latency,Amplitude
49
56
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=en&sid=1
Mehrdad
Bakhtyari
137003194753284600418
137003194753284600418
Yes
Department of Anatomy and Neuroscience Research Center, Iran University of Medical Sciences,
Hamid
Abootaleb
137003194753284600419
137003194753284600419
No
Department of Anatomy and Neuroscience Research Center, Iran University of Medical Sciences,
Korosh
Mansouri
137003194753284600420
137003194753284600420
No
Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences,