Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1392
1
1
gregorian
2013
4
1
4
2
online
1
fulltext
en
Cell Therapy in Spinal Cord Injury: a Mini- Reivew
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p align="left" ><p><font color="#221e1f" size="1"><font color="#221e1f" size="1">Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1">our more recent strategy was application of cytokines. We observed a significant improvement </font></font></font><font color="#221e1f" size="1"><font color="#221e1f" size="1">in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI. </font></font></p>
Spinal Cord Injury,Stem Cell,Regeneration,Olfactory Mucosa,Schwann Cells,Bone Marrow Stromal Cells,Stromal Derived Factor.
172
177
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-158&slc_lang=en&sid=1
Soraya
Mehrabi
1370031947532846003893
1370031947532846003893
No
Sanaz
Eftekhari
1370031947532846003894
1370031947532846003894
No
bFateme
Moradi
1370031947532846003895
1370031947532846003895
No
Hamdollah
Delaviz
1370031947532846003896
1370031947532846003896
No
Bagher
Pourheidar
1370031947532846003897
1370031947532846003897
No
Monir
Azizi
1370031947532846003898
1370031947532846003898
No
Adib
Zendehdel1
1370031947532846003899
1370031947532846003899
No
Ali
Shahbazi
1370031947532846003900
1370031947532846003900
No
Mohammad Taghi
Joghataei
1370031947532846003901
1370031947532846003901
Yes