Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1389
2
1
gregorian
2010
5
1
1
3
online
1
fulltext
en
The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p align="justify"><strong>A B S T R A C T</strong></p><p align="justify"> <strong>Introduction</strong>: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & <strong>Methods</strong>: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. </p><p align="justify"><strong>Results</strong>: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group.</p><p align="justify"><strong> Discussion</strong>: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat. </p>
Ischemia-Reperfusion,Diazoxide,Ultrastructural Changes
17
20
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-28&slc_lang=en&sid=1
Mehdi
Mehdizadeh
137003194753284600390
137003194753284600390
Yes
Department of Anatomy, School of Medicine, Iran University of Medical Sciences
Majid
Katebi
137003194753284600391
137003194753284600391
No
Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences
Mansoure
Soleimani
137003194753284600392
137003194753284600392
No
Department of Anatomy, School of Medicine, Iran University of Medical Sciences
Mohammad Hassan
Farahani Pad
137003194753284600393
137003194753284600393
No
School of Medicine, Azad University
Ali
Hoseini Tehrani
137003194753284600394
137003194753284600394
No
School of Medicine, Azad University
Mohammad
Taghi Joghataei
137003194753284600395
137003194753284600395
No
Department of Anatomy, School of Medicine, Iran University of Medical Sciences