Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1391
5
1
gregorian
2012
8
1
3
4
online
1
fulltext
en
Comparing the Effectiveness of Paroxetine, Attention Modification Program and Combination of both on Improving Social Anxiety Symptoms
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p align="left" ><p><b><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Although the effectiveness of paroxetine and Attention Modification </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Program has been studied separately in treating social anxiety disorder, there has been no research comparing them according to the literature. The aim of this study </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">was to compare the effectiveness of paroxetine, Attention Modification Program </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">(AMP) and combination of both on improving the Social Anxiety Symptoms. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify">Methods: </p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">33 patients meeting DSM-IV-TR criteria for social anxiety disorder were randomly assigned in 3 groups: 11 in paroxetine group, 11 in AMP group and 11 in combined group. Treatment intervention was done during 8 weeks period. Social Phobia Inventory (SPIN), Beck Depression Inventory (BDI-II) and Sheehan Disability Scale (SDS) were administered before and after treatment intervention. One-way Analysis of Covariance (ANCOVA) was used to determine </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">the differences and efficacy of treatment interventions between groups. Data </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">analysis was done by SPSS-16 software. </font></font></font><b><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><p align="justify">Results: </p></font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">28 participants completed the treatment period. One-way ANCOVA </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">results showed statistically significant differences in post-treatment scores of </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">social phobia (p=0/007), depressive symptoms (p=0.007) and daily life functioning (p=0.011) between three groups. Bonferroni correction showed that combined </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">treatment is significantly more effective than AMP in reducing social phobia </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">symptoms (p=0.007), depressive symptoms (p=0.022) and enhancing daily life </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">functioning (0.019). Yet, there were no significant differences between Paroxetine </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">and combined treatment in all post-treatment scores (p=0.890, p=1.000, p=1.000 for social phobia, depressive symptoms and daily life functioning respectively). </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Paroxetine showed more significant improvement of depressive symptoms </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">(p=0.016) and enhancing daily life functioning (p=0.045) than AMP. Also, there </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">were no significant differences between paroxetine and AMP in reducing social </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">anxiety symptoms. </font></font></font><b><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><p>Discussion: </p></font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">It seems that paroxetine has wider effect in reducing social anxiety symptoms, depressive symptoms and enhancing daily life functioning than </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">AMP and adding the AMP to paroxetine does not make significant changes than </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">medicating with paroxetine alone. </font></font></font></b></b></b></b></p>
Paroxetine, Attention Modification Program, Social Anxiety, Social phobia
36
44
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-118&slc_lang=en&sid=1
Hosein
Khedmatgozar
1370031947532846002050
1370031947532846002050
Yes
Behrooz
Birashk
1370031947532846002051
1370031947532846002051
No
Hassan
Ashayeri
1370031947532846002052
1370031947532846002052
No
Aliasghar
Asgharnejad Farid
1370031947532846002053
1370031947532846002053
No