Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1401
8
1
gregorian
2022
11
1
13
6
online
1
fulltext
en
Alteration in Neuregulin 1/ERbB4 in Absence Epilepsy: Regulatory Effect on TRPV1 Expression
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: The footprint of Neuregulin 1 (NRG1) / ERbB4 in the pathophysiology of some neurological disorders and TRPV1 regulation has been indicated. The alterations in NRG1 and ErbB4 as well as the TRPV1 signaling pathway were investigated during the development of absence epilepsy in the genetic animal model of absence epilepsy.<br>
<strong>Methods</strong>: Male WAG/Rij and Wistar rats were divided into four experimental groups of two and six months of age. The protein levels of NRG1, ERbB4, and TRPV1 were measured in the somatosensory cortex and hippocampus. <br>
<strong>Results</strong>: The cortical protein levels of NRG1 and ErbB4 in the 6-month-old WAG/Rij rats were lower than in Wistar rats. Protein levels of TRPV1 were lower in two- and six-month-old WAG/Rij rats compared to age-matched Wistar rats.<br>
Hippocampal protein levels of NRG1 in 6-month-old WAG/Rij rats were lower than two-month-old WAG/Rij rats. Low levels of ErbB4 protein in two-month-old and high levels in six-month-old WAG/Rij rats were found compared to Wistar rats. Protein levels of TRPV1 were lower in the two-month-old and higher in the six-month-old WAG/Rij rats compared to age-matched Wistar rats. <br>
Furthermore, a high correlation between NRG1/ERbB4 and TRPV1 expressions in the cortex and hippocampus was indicated. The expression of NRG1/ERbB4 and TRPV1 followed a similar pattern during the life span of Wistar and WAG/Rij rats.<br>
<strong>Conclusion</strong>: Our findings indicated the potential role of the NRG1/ErbB4 pathway as well as TRPV1 in the pathogenesis of absence epilepsy. The regulatory effect of the ERbB4 receptor on the TRPV1 expression has been suggested following the similar pattern of expression.</div>
Epilepsy, Cerebral Cortex, Neuregulins, Transient Receptor Potential Channels, Receptor, ErbB-4
777
788
http://bcn.iums.ac.ir/browse.php?a_code=A-10-731-2&slc_lang=en&sid=1
Farideh
Talebi
talebi_f@hotmail.com
13700319475328460043467
13700319475328460043467
No
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Samira
Ghorbani
sgsamsahara@gmail.com
13700319475328460043468
13700319475328460043468
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Leila
Alizadeh
talebi_f@hotmail.com
13700319475328460043469
13700319475328460043469
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Fatemeh
Akhlaghi
talebi_f@hotmail.com
13700319475328460043470
13700319475328460043470
No
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sedigheh Sadat
Moeeni
talebi_f@hotmail.com
13700319475328460043471
13700319475328460043471
No
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Fariba
Karimzadeh
karimzade.f@iums.ac.ir
13700319475328460043472
13700319475328460043472
Yes
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.