Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1390
7
1
gregorian
2011
10
1
3
1
online
1
fulltext
en
Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<p align="left" ><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="left" ><p><strong><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. </font></font></font></strong><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify"><strong>Methods: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify"><strong>Results: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p><strong>Discussion: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. </font></font></font></p></font></font>
Apoptosis,N-Methyl-3,4-Methylenedioxyamphetamine,Acetylcysteine
44
47
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=1
Sara
Soleimani Asl
1370031947532846001434
1370031947532846001434
Yes
Peiman
Falahati
1370031947532846001435
1370031947532846001435
No
Nima
shekar riz
1370031947532846001436
1370031947532846001436
No
Nima
Molavi
1370031947532846001437
1370031947532846001437
No
Farzaneh
Esmaeili
1370031947532846001438
1370031947532846001438
No
Zahra
Azimi
1370031947532846001439
1370031947532846001439
No
Freidoon
Sajadi
1370031947532846001440
1370031947532846001440
No
Parisa
Hayat
1370031947532846001441
1370031947532846001441
No
Alireza
Samzadeh-Kermani
1370031947532846001442
1370031947532846001442
No
Mehdi
Mehdizadeh
1370031947532846001443
1370031947532846001443
No