Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1398
12
1
gregorian
2020
3
1
11
2
online
1
fulltext
en
The Role of Anxiety and Cortisol in Outcomes of Patients With Covid-19
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<strong>Introduction:</strong> The outbreak due to Coronavirus Disease 2019 (COVID-19) is n global public health emergency and challenges psychological resilience. The central nervous system, endocrine system, and immune system are complex interacting systems. Cortisol has been implicated as the cause of a wide range of mental and physical health disorders; however, the impact of cortisol on outcomes in patients with COVID-19 is not clear.<br>
<strong>Methods:</strong> The current study enrolled patients with COVID-19 (onset of disease within 7 days of the first symptom) to evaluate the serum concentration of cortisol and levels of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) to investigate a possible relationship between cortisol, depression, and anxiety levels and outcomes of patients with COVID-19. <br>
<strong>Results:</strong> A total of 30 patients with COVID-19 were studied. The levels of cortisol and HADS score in patients who died of Covid-19 were significantly higher in comparison with surviving patients (P<0.017 and P<0.001 respectively). We also found that the HADS score was positively correlated with serum cortisol levels (r= 0.842, P=0.004). <br>
<strong>Conclusion:</strong> Our findings showed that stress and anxiety are associated with patients’ outcomes. Psychological interventions can improve the mental health of vulnerable groups during the COVID-19 epidemic.
COVID-19, Stress, Cortisol, Anxiety
179
184
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1168-2&slc_lang=en&sid=1
Mahtab
Ramezani
drramezani96@gmail.com
13700319475328460025974
13700319475328460025974
No
Skull-Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Leila
Simani
l.simani62@gmail.com
13700319475328460025975
13700319475328460025975
Yes
Skull-Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ehsan
Karimialavijeh
13700319475328460025976
13700319475328460025976
No
Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Omidvar
Rezaei
13700319475328460025977
13700319475328460025977
No
Skull-Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammadreza
Hajiesmaeili
13700319475328460025978
13700319475328460025978
No
Anesthesiology Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein
Pakdaman
13700319475328460025979
13700319475328460025979
No
Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.