Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1390
5
1
gregorian
2011
8
1
2
4
online
1
fulltext
en
Effect of Different Doses of Soy Isoflavones on Spatial Learning and Memory in Ovariectomized Rats
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<p align="left"><b><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">Several studies indicate that estrogen use increase performance on some tests of cognition especially in postmenopausal women. These steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. The main objection of this study was to evaluate the effects of different doses of dietary soy meals (with or without isoflavone) on spatial learning and memory in ovariectomized (OVX) rats. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify">Methods: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">Female Wistar rats with the exception of intact group were ovariectomized at the first line of study. Subjects were divided into six groups. The control group rats (c) were gonadally intact, while the others were OVX. OVX groups received normal diet (0), treated with 10 gr soy (10), 20 gr soy (20), 10 gr isoflavone free soy (-10) or 20 gr isoflavone free soy (-20) in daily diet for four weeks. The spatial learning and memory were tested using Morris water maze. Rats were trained in water maze to find a hidden escape Platform. Rats received 6 blocks that each block consisted of 3 trials. Following acquisition trials, one probe trial were conducted in which the platform was removed. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify">Results: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">Soy meal diet (with or without isoflavone) in ovariectomized rats caused improvement of performance across 18 trials of Acquisition. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p>Discussion: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">Our results suggest that soy consumption apart from containing isoflavone or not is a potential alternative to estrogen in the improvement of cognition. </font></font></font></b></b></b></b></p>
Soy,Isoflavone,Morris water maze,Ovariectomy,Rat.
12
18
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-71&slc_lang=en&sid=1
Maryam
Safahani
1370031947532846001185
1370031947532846001185
Yes
Reza
Amani
1370031947532846001186
1370031947532846001186
No
Hadi
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1370031947532846001187
1370031947532846001187
No
Alireza
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1370031947532846001188
1370031947532846001188
No
Mohammad
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1370031947532846001189
1370031947532846001189
No
Ahmad
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1370031947532846001190
1370031947532846001190
No
M.Hosein
Haghighizadeh
1370031947532846001191
1370031947532846001191
No