Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1390
5
1
gregorian
2011
8
1
2
4
online
1
fulltext
en
The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<p align="left"><b><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo). </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify">Results: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p>Discussion: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions. </font></font></font></b></b></b></b><p></p></p><p align="justify">Methods: </p>
Music,Elevated plus-maze,Open-field,Rattus norvegicus,Simvastatin.
5
11
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-70&slc_lang=en&sid=1
Júlia
Niehues da Cruz
1370031947532846001181
1370031947532846001181
No
Universidade do Extremo Sul Catarinense, Santa Catarina, Brazil
Daniela
Delwing de Lima
1370031947532846001182
1370031947532846001182
No
Universidade da Região de Joinville, Santa Catarina, Brazil
Débora
Delwing Dal Magro
1370031947532846001183
1370031947532846001183
No
Universidade Regional de Blumenau, Santa Catarina, Brazil
José
Geraldo Pereira da Cruz
1370031947532846001184
1370031947532846001184
Yes
Department of Natural Sciences, Universidade Regional de Blumenau, Santa Catarina, Brazil