Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1400
10
1
gregorian
2022
1
1
13
1
online
1
fulltext
en
The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction:</strong> Alzheimer disease (AD) is a complex neurodegenerative disorder with a progressive nature leading to neural damage and cognitive and memory deficit. The present study investigated the neuroprotective effects of Centella asiatica (CA) in Streptozotocin (STZ)-induced rat model of memory impairment and neuronal damage.<br>
<strong>Methods:</strong> The intracerebroventricular infusion of STZ (3 mg/rat) or saline (as the vehicle) was performed on days 1 and 3. CA (150 and 300 mg/kg/d) was administered through oral gavage for 21 days after model induction. We used the Y-maze test to assess the working memory-related performances of animals. Rats were then sacrificed, and their hippocampi were harvested for evaluation of neuronal density in the cornu ammonis (CA1, CA2, CA3) and Dentate Gyrus (DG) regions using stereology technique.<br>
<strong>Results:</strong> The intracerebroventricular infusion of STZ caused significant working memory impairment demonstrated in the Y-maze apparatus, with a significant decrease in alternative behavior compared to control animals (40.67±2.04 vs 73.00±1.88, P<0.0001). Oral administration of CA (150 and 300 mg/kg each day) for 21 days significantly improved STZ-induced working memory deficit (55.33±3.34 and 57.17±3.81 vs 40.67±2.04, P<0.013, P<0.004, respectively). Furthermore, 21 days of consecutive administration of CA significantly ameliorated STZ-induced neuronal loss in the CA1, CA2, and DG subfields of the hippocampus. <br>
<strong>Conclusion:</strong> Overall, these data demonstrate that CA increases neuronal density and improves cognitive impairment in the STZ-induced rat model of AD, thereby having promising therapeutic potential for neurodegenerative disorders. Accordingly, further studies are needed to determine the exact molecular mechanism of CA protective effects in brain disorders, particularly AD.<br>
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Alzheimer disease, Working memory, Centella asiatica, Neuron Degeneration
25
34
http://bcn.iums.ac.ir/browse.php?a_code=A-10-144-4&slc_lang=en&sid=1
Razyeh
Sahraei
rozsahra100@gmail.com
13700319475328460040427
13700319475328460040427
No
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Samaneh
Aminyavari
Samaneh.aminyavari@gmail.com
13700319475328460040428
13700319475328460040428
No
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehran
Hosseini
mehranhosseiny@yahoo.co.in
13700319475328460040429
13700319475328460040429
No
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Mohammadmehdi
Hassanzadeh-Taheri
Mmhtahery35@gmail.com
13700319475328460040430
13700319475328460040430
No
Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Mohsen
Foadoddini
Foadmohsen@yahoo.com
13700319475328460040431
13700319475328460040431
No
Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Mohammadreza
Saebipour
saebipour@gmail.com
13700319475328460040432
13700319475328460040432
Yes
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.