Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1399
4
1
gregorian
2020
7
1
11
4
online
1
fulltext
en
The Effects of Ripe Pistachio Hulls Hydro-alcoholic Extract and Aerobic Training on Learning and Memory in Streptozotocin-induced Diabetic Male Rats
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<strong>Introduction</strong>: Diabetes mellitus has harmful effects on body functions, such as learning and memory. According to the role of exercise and medicinal plants on body health, the purpose of this study was to survey the effect of combined aerobic training and the use of Ripe Pistachio Hulls (RPH) hydro-alcoholic extract on learning and memory in streptozotocin-induced diabetic male rats.<br>
<strong>Methods</strong>: In this experimental study, 42 male Wistar rats weighing 250-280 g were used in 6 groups with an equal number of 7 rats in each one. Streptozotocin (STZ) (50 mg / kg)was used to induce diabetes , and the test protocol was applied for 8 weeks. Passive avoidance memory was assessed using a step-through passive avoidance apparatus (shuttle box). SPSS software was used to analyze the data and P<0.05 was significant.<br>
<strong>Results</strong>: The results showed that step-through latency in the acquisition trial (STLa) was not significantly different among groups. Step-through latency in retrieval (STLr 24) test significantly reduced and time spent in The Dark Compartment (TDC) decreased in treated groups compared with the diabetic control groups (P<0.001). Also, there was no significant difference between the STZ and saline diabetic groups.<br>
<strong>Conclusion</strong>: The findings of this study revealed that the RPH hydro-alcoholic extract and aerobic exercise could improve passive avoidance memory in streptozotocin diabetic rats. Meanwhile, they might be an adjuvant therapy combined with other traditional medicine.
Ripe pistachio Hulls, Aerobic Training, Learning and memory, Streptozotocin-diabetic rats
525
534
http://bcn.iums.ac.ir/browse.php?a_code=A-10-510-2&slc_lang=en&sid=1
Sajad
Abdi Gorabi
sajad.abdi2015@gmail.com
13700319475328460029104
13700319475328460029104
No
Department of Motor Behavior, Faculty of Physical Education and Sport Sciences, University of Urmia, Urmia, Iran.
Hasan
Mohammadzadeh
h.mohammadzadeh@urmia.ac.ir
13700319475328460029105
13700319475328460029105
No
Department of Motor Behavior, Faculty of Physical Education and Sport Sciences, University of Urmia, Urmia, Iran.
Mohammad
Rostampour
ostampour@gums.ac.ir
13700319475328460029106
13700319475328460029106
Yes
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.