Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1397
12
1
gregorian
2019
3
1
10
2
online
1
fulltext
en
Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction:</strong> The long-term adverse effects of transient thyroid function abnormalities at birth on intellectual development are proven. The effect of exercise increases in the presence of sex hormones. The current study aimed at investigating the possibility that a combination of sex hormones and exercise has synergistic effects on neural plasticity in Transient Congenital Hypothyroidism (TCH) rats. <br>
<strong>Methods:</strong> To induce hypothyroidism in the mothers, Propylthiouracil (PTU) was added to drinking water (100 mg/L) on the 6th day of gestation and continued until the 21st Postnatal Day. From Postnatal Day (PND) 28 to 47, the female and male pups received 17β-estradiol and testosterone, respectively. The mild treadmill exercise began 30 minutes after the sex hormones or vehicle administration. On PND 48, electrophysiological experiments were performed on brain slices. <br>
<strong>Results:</strong> Increase of Long-Term Potentiation (LTP) was observed in sedentary-non-hormone female rats of TCH group, compared with that of the control. The exercise enhanced LTP in control rats, but the hormones showed no significant effect. The effect of exercise and sex hormone was not significant in the TCH group. The combination of exercise and testosterone enhanced LTP in TCH male rats, while the combination of exercise and estradiol or each of them individually did not produce such an effect on LTP in TCH female rats. <br>
<strong>Conclusion:</strong> The study findings showed an increase in excitatory transmission despite the returning of thyroid hormone levels to normal range in TCH female rats. Also a combination treatment including exercise and testosterone enhanced LTP in male rats of TCH group, which was a gender-specific event.</div>
Exercise, Hypothyroid, Sex hormones, Long-Term Potentiation
119
136
http://bcn.iums.ac.ir/browse.php?a_code=A-10-349-2&slc_lang=en&sid=1
Leila
Derafshpour
Leila_d56@yahoo.com
13700319475328460019544
13700319475328460019544
No
Laboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Ehsan
Saboory
saboory@umsu.ac.ir
13700319475328460019545
13700319475328460019545
Yes
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Abbas Ali
Vafaei
aavaf43@yahoo.com
13700319475328460019546
13700319475328460019546
No
Laboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Ali
Rashidy-Pour
rashidy-pour@semums.ac.ir
13700319475328460019547
13700319475328460019547
No
Laboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Shiva
Roshan-Milani
hiva_muk@yahoo.com
13700319475328460019548
13700319475328460019548
No
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Yosef
Rasmi
Yosef Rasmi
13700319475328460019549
13700319475328460019549
No
Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Yosef
Panahi
panahiy@ymail.com
13700319475328460019550
13700319475328460019550
No
Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Hamidreza
Sameni
hrsameni@gmail.com
13700319475328460019551
13700319475328460019551
No
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.