AU - Hajipour, Somayeh AU - Sarkaki, Alireza AU - Farbood, Yaghoob AU - Eidi, Akram AU - Mortazavi, Pejman AU - Valizadeh, Zohreh TI - Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 7 VI - 2 IP - 2 4099 - http://bcn.iums.ac.ir/article-1-579-en.html 4100 - http://bcn.iums.ac.ir/article-1-579-en.pdf SO - BCN 2 ABĀ  - Introduction: To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by betaamyloid (Aβ). Methods: Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP). Results: Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01). Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats. CP - IRAN IN - Department of Nursing and Midwifery, Dezfoul Branch, Islamic Azad University, Dezfoul, Iran. LG - eng PB - BCN PG - 97 PT - Original YR - 2016