AU - Zamanian-Azodi, Mona AU - Rezaei-Tavirani, Mostafa AU - Robati, Reza Mahmoud TI - Introducing Genes With Significant Role in Migraine: An Interactomic Approach PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 10 VI - 4 IP - 4 4099 - http://bcn.iums.ac.ir/article-1-1351-en.html 4100 - http://bcn.iums.ac.ir/article-1-1351-en.pdf SO - BCN 4 ABĀ  - Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened. Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. CP - IRAN IN - LG - eng PB - BCN PG - 363 PT - Original YR - 2019