TY - JOUR T1 - The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats TT - JF - BCN JO - BCN VL - 5 IS - 2 UR - http://bcn.iums.ac.ir/article-1-369-en.html Y1 - 2014 SP - 124 EP - 130 KW - Kainic Acid KW - Berberine KW - Seizure KW - Hippocampus KW - Oxidative Stress KW - Rat N2 - Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. In this study, we investigated the possible neuroprotective effect of berberine in an intrahippocampal kainate model of TLE in rat. Methods: In the present study, the anticonvulsant and antioxidant effects of intraperitoneal administration of berberine(25, 50 and 100 mg/kg), was evaluated in intrahippocampal kainate(4g)-induced TLE in rats. Results: The results showed that the kainate rats exhibit acute and spontaneous seizures in 24 hours and two weeks after intrahippocampal kainic acid injection. Administration of berberine, significantly decreased Racine score and rate of incidence of seizure in kainate rats(P M3 ER -