TY - JOUR T1 - A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case TT - JF - BCN JO - BCN VL - 8 IS - 4 UR - http://bcn.iums.ac.ir/article-1-710-en.html Y1 - 2017 SP - 337 EP - 343 KW - Mitochondrial disorder KW - MELAS Syndrome KW - Middle age N2 - Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy. Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures. M3 10.18869/nirp.bcn.8.4.337 ER -