AU - Almasi, Mostafa AU - Motamed, Mohammad Reza AU - Mehrpour, Masoud AU - Haghi-Ashtiani, Bahram AU - Haji Akhondi, Fahimeh AU - Nilipour, Yalda AU - Fereshtehnejad, Seyed-Mohammad TI - A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 8 VI - 4 IP - 4 4099 - http://bcn.iums.ac.ir/article-1-710-en.html 4100 - http://bcn.iums.ac.ir/article-1-710-en.pdf SO - BCN 4 ABĀ  - Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy. Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures. CP - IRAN IN - Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. LG - eng PB - BCN PG - 337 PT - Original YR - 2017