%0 Journal Article %A Almasi, Mostafa %A Motamed, Mohammad Reza %A Mehrpour, Masoud %A Haghi-Ashtiani, Bahram %A Haji Akhondi, Fahimeh %A Nilipour, Yalda %A Fereshtehnejad, Seyed-Mohammad %T A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case %J Basic and Clinical Neuroscience Journal %V 8 %N 4 %U http://bcn.iums.ac.ir/article-1-710-en.html %R 10.18869/nirp.bcn.8.4.337 %D 2017 %K Mitochondrial disorder, MELAS Syndrome, Middle age, %X Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy. Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures. %> http://bcn.iums.ac.ir/article-1-710-en.pdf %P 337-343 %& 337 %! %9 Original %L A-10-862-1 %+ Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. %G eng %@ 2008-126X %[ 2017