@ARTICLE{Almasi, author = {Almasi, Mostafa and Motamed, Mohammad Reza and Mehrpour, Masoud and Haghi-Ashtiani, Bahram and Haji Akhondi, Fahimeh and Nilipour, Yalda and Fereshtehnejad, Seyed-Mohammad and }, title = {A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case}, volume = {8}, number = {4}, abstract ={Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy. Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures. }, URL = {http://bcn.iums.ac.ir/article-1-710-en.html}, eprint = {http://bcn.iums.ac.ir/article-1-710-en.pdf}, journal = {Basic and Clinical Neuroscience Journal}, doi = {10.18869/nirp.bcn.8.4.337}, year = {2017} }