%0 Journal Article %A Soleimani Asl, Sara %A Ghasemi Moravej, Fahimeh %A Kowsari, Golshad %A Farhadi, Mohammad Hassan %A Pourhaydar, Bagher %A Ghasemi Hamidabadi, Hatef %A Mehdizadeh, Mehdi %T The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats %J Basic and Clinical Neuroscience Journal %V 11 %N 4 %U http://bcn.iums.ac.ir/article-1-1267-en.html %R 10.32598/bcn.9.10.420 %D 2020 %K N-Methyl-3, 4-methylenedioxyamphetamine, Hippocampus, Nestin, Sox2 Protein, NeuroD Protein, %X Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells. %> http://bcn.iums.ac.ir/article-1-1267-en.pdf %P 457-464 %& 457 %! %9 Original %L A-10-618-6 %+ Department of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. %G eng %@ 2008-126X %[ 2020