TY - JOUR JF - BCN JO - BCN VL - 8 IS - 3 PY - 2017 Y1 - 2017/5/01 TI - Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study TT - N2 - Introduction: The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ) -induced memory impairment. Methods: Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task. Results: In the MWM, Aβ (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the Aβ-induced memory impairment in the MWM task. Conclusion: The current study findings showed that C. Rotundus could improve the learning impairment, following the Aβ treatment, and it may lead to an improvement of AD-induced cognitive dysfunction. SP - 249 EP - 254 AU - Mehdizadeh, Mehdi AU - Hashem Dabaghian, Fataneh AU - Shojaee, Asie AU - Molavi, Nima AU - Taslimi, Zahra AU - Shabani, Ronak AU - Soleimani Asl, Sara AD - Endometrium and Endometriosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran. KW - Alzheimer disease KW - Amyloid β-peptide KW - Cyperus rotundus KW - Spatial memory UR - http://bcn.iums.ac.ir/article-1-702-en.html DO - 10.18869/nirp.bcn.8.3.249 ER -