AU - Nasehi, Mohammad TI - The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 6 VI - 3 IP - 3 4099 - http://bcn.iums.ac.ir/article-1-560-en.html 4100 - http://bcn.iums.ac.ir/article-1-560-en.pdf SO - BCN 3 ABĀ  - Introduction: The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-HT) system on cognitive and non-cognitive behaviors. Thus, the purpose of this study is to assess the effects of hippocampal 5-HT4 receptor on memory acquisition deficit induced by harmaline. Methods: Harmaline was injected peritoneally, while 5-HT4 receptor agonist (RS67333) and antagonist (RS23597-190) were injected intra-hippocampal. A single-trial step-down passive avoidance, open field and tail flick tasks were used for measurement of memory, locomotor activity and pain responses, respectively. Results: The data revealed that pre-training injection of higher dose of harmaline (1 mg/kg), RS67333 (0.5 ng/mouse) and RS23597-190 (0.5 ng/mouse) decreased memory acquisition process in the adult mice. Moreover, concurrent pre-training administration of subthreshold dose of RS67333 (0.005 ng/mouse) or RS23597-190 (0.005 ng/mouse) with subthreshold dose of harmaline (0.5 mg/kg, i.p.) intensify impairment of memory acquisition. All above interventions did not change locomotion and tail flick behaviors. Discussion: The results demonstrated that the synergistic effect between both hippocampal 5-HT4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for hippocampal 5HT4 receptor on Harmaline induced amnesia. CP - IRAN IN - Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Garmsar Branch, Garmsar, Iran LG - eng PB - BCN PG - 163 PT - Original YR - 2015