TY - JOUR JF - BCN JO - BCN VL - 6 IS - 1 PY - 2015 Y1 - 2015/2/01 TI - Group A β-hemolytic Streptococcal Infection in Children and the Resultant Neuro-psychiatric Disorder a Cross Sectional Study Tehran, Iran TT - N2 - Introduction: Group A Beta-Hemolytic Streptococcus (GABHS) can induce PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection). GABHS is the most important and common bacterial cause of acute pharyngitis in Iranian children. We studied the role of GABHS (anti-streptococcal antibodies) in suspected cases of PANDAS in a cross sectional studies. Methods: Across sectional study was done in 2 pediatric psychiatric /and neurologic clinics in Tehran (Rasul Akram and Aliasghar Hospital) during 2008-2010. We studied serum antistreptococcal antibodies (anti streptolysin O, anti Deoxyribonuclease B, and anti-streptokinase (ABcam-ELISA, USA) in 76 cases with psychiatric manifestation (OCD, ADHD) in compare with 39 healthy controls. These antibodies were studied in 53 cases with movement disorders (Tic/ Tourette syndrome ) in compare with 76 healthy controls. Sensitivity, specificity and positive predictive value of tests were calculated. Results: In movement disorders ASOT, Anti-DNase and Anti streptokinase was significantly higher than controls (p 332 IU/ml) had 34% sensitivity 85% specificity, and 72% PPV Anti-DNase (cut off level> 140IU/ml) had 70% sensitivity 99% specificity and PPV 90% for differentiating the group. ASOT, Anti-DNase and Anti streptokinase titer was significantly higher than controls (p SP - 38 EP - 43 AU - Ebrahimi Taj, Farideh AU - Noorbakhsh, Samileh AU - Ghavidel Darestani, Sahar AU - Shirazi, Elham AU - Javadinia, Shima AD - Department of Pediatric Psychology, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran KW - Group A ß-hemolytic streptococcus (GABHS) KW - PANDAS (pediatric autoimmune neuropsychiatric disorders) KW - OCD (obsessive-compulsive disorder) KW - ADHD syndrome (attention deficient hyperactive disorders) KW - Tic KW - Tourette syndrome . UR - http://bcn.iums.ac.ir/article-1-319-en.html ER -