AU - Nozari, Masoumeh AU - Nahavandi, Arezo AU - Zeinivand, Motahareh AU - Eslami Gharaati, Maryam AU - Godarzi, Mina AU - Ahmadi, Mohammad AU - Jamali-Raeufy, Nida TI - Ibuprofen Protection Against Restrained Chronic Stress-induced Depression in Male Rats PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 11 VI - 4 IP - 4 4099 - http://bcn.iums.ac.ir/article-1-1472-en.html 4100 - http://bcn.iums.ac.ir/article-1-1472-en.pdf SO - BCN 4 ABĀ  - Introduction: Stress predisposes organisms to depression and cognitive impairments, and seems to interact with metabolic homeostasis. The inflammatory response and the upregulation of proinflammatory cytokines are some of the consequences related to chronic stress. In this study, we investigated the preventive effect of chronic administration of ibuprofen, as an inhibitor of cyclooxygenases, on the cognitive and behavioral alterations and the weight gain reduction induced by simultaneous chronic restraint stress in rats. Materials and Methods: Male Wistar rats were subjected to chronic restraint stress and injected daily with the variable doses of ibuprofen or vehicle, for 21 consecutive days. Then, all animals were tested with the forced swim test and passive avoidance conditioning. Also, the weight of the animals was recorded before and after the interventions. Ultimately, plasma interleukin 6 (IL-6) levels were measured. Results: Chronic stress increased depressive-like behaviors, impaired learning, and disrupted the normal weight gain. However, the animals that received the highest dose of ibuprofen showed less depressive-like behaviors, a better avoidance memory, and a higher weight gain. However, the level of plasma IL-6 did not differ significantly between the study groups. Conclusion: The administration of ibuprofen prevents the cognitive and behavioral consequences of chronic stress. During the recovery, the plasma levels of IL-6 were not elevated by stress, and the IL-6 levels did not predict the behavioral performance of the stressed animals. The exact mechanisms of the protective effects of ibuprofen against chronic stress need to be further investigated. CP - IRAN IN - Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2 Student Research Committee, Iran University of Medical Sciences, Tehran, Iran LG - eng PB - BCN PG - 413 PT - Original YR - 2020