RT - Journal Article T1 - Effects of Dextromethorphan on Depressive- and Cognitive-Associated Behaviors: A Sexually Dimorphic Study JF - BCN YR - 2019 JO - BCN VO - 10 IS - 4 UR - http://bcn.iums.ac.ir/article-1-1226-en.html SP - 393 EP - 400 K1 - Dextromethorphan K1 - Depression K1 - Cognition K1 - Hippocampus K1 - Female K1 - Male AB - Introduction: We investigated the sexually dimorphic effects of Dextromethorphan (DM) on cognitive and depression-like behaviors as well as on hippocampal histology in rats following acute administration. Methods: Wistar rats of both sexes were treated with 25 or 50 mg/kg of DM for 7 days via intraperitoneal injection. At the end of the administration, behavioral studies were performed on the Tail Suspension Test (TST) for depressive-like behaviors and the Y-maze for cognitive behaviors. The rats’ brains were excised and processed for routine histological analysis. Results: Our results showed that DM significantly increased (P<0.05) immobility time in the TST in male rats but not female ones, and decreased percentage alternation (P<0.001) on the Y-maze in both male and female rats. Histological analysis revealed no morphological changes in the hippocampus following DM treatment. Conclusion: DM impairs cognitive functions in both male and female rats without histologic defects in the hippocampus. However, the induced depressive-like behaviors following DM administration may be sexually dependent. LA eng UL http://bcn.iums.ac.ir/article-1-1226-en.html M3 10.32598/bcn.9.10.275 ER -