%0 Journal Article %A Talimkhani, Ailin %A Abdollahi, Iraj %A Mohseni-Bandpei, Mohammad Ali %A Ehsani, Fatemeh %A Khalili, Sanaz %A Jaberzadeh, Shapour %T Differential Effects of Unihemispheric Concurrent Dual-Site and Conventional tDCS on Motor Learning: A Randomized, Sham-Controlled Study %J Basic and Clinical Neuroscience Journal %V 10 %N 1 %U http://bcn.iums.ac.ir/article-1-1057-en.html %R 10.32598/bcn.9.10.350 %D 2019 %K Transcranial direct current stimulation, Primary motor cortex, Dorsolateral prefrontal cortex, Learning, Motor skills, %X Introduction: Based on the literature, unihemispheric concurrent dual-site anodal transcranial Direct Current Stimulation (a-tDCSUHCDS) of primary Motor cortex (M1) and Dorsolateral Prefrontal Cortex (DLPFC) would be more efficient than conventional a-tDCS of M1 to induce larger and longer-lasting M1 corticospinal excitability. The main objective of the present study was to compare the effects of a-tDCSUHCDS and conventional M1 a-tDCS on the extent and durability of the motor sequence acquisition in healthy individuals. Methods: In this randomized sham-controlled study, healthy volunteers were randomly divided into three groups: experimental (a-tDCSUHCDS), control (M1 a-tDCS), and sham stimulation groups. The participants practiced serial response time task over three consecutive days when they simultaneously received a-tDCS. Using the skill measure, we assessed motor learning up to 4 weeks after the completion of experimental conditions. Results: Data analysis revealed that all groups exhibited the improved trend over the training course (P<0.001). There were no significant differences in skill acquisition among groups at post-intervention (P>0.05), while a significant improvement was observed between experimental and sham group at the retention time (P<0.05). Moreover, there were no significant differences between the control and two other groups with regard to the retention time (P>0.05). Conclusion: These results revealed a significant increase in the skill acquisition by a-tDCSUHCDS technique with regard to retention issue, which could be a valuable finding in neuro-rehabilitation field. %> http://bcn.iums.ac.ir/article-1-1057-en.pdf %P 59-72 %& 59 %! %9 Original %L A-10-1244-2 %+ Department of Physical Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. %G eng %@ 2008-126X %[ 2019