@ARTICLE{Simani, author = {Ramezani, Mahtab and Simani, Leila and Karimialavijeh, Ehsan and Rezaei, Omidvar and Hajiesmaeili, Mohammadreza and Pakdaman, Hossein and }, title = {The Role of Anxiety and Cortisol in Outcomes of Patients With Covid-19}, volume = {11}, number = {2}, abstract ={Introduction: The outbreak due to Coronavirus Disease 2019 (COVID-19) is n global public health emergency and challenges psychological resilience. The central nervous system, endocrine system, and immune system are complex interacting systems. Cortisol has been implicated as the cause of a wide range of mental and physical health disorders; however, the impact of cortisol on outcomes in patients with COVID-19 is not clear. Methods: The current study enrolled patients with COVID-19 (onset of disease within 7 days of the first symptom) to evaluate the serum concentration of cortisol and levels of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) to investigate a possible relationship between cortisol, depression, and anxiety levels and outcomes of patients with COVID-19. Results: A total of 30 patients with COVID-19 were studied. The levels of cortisol and HADS score in patients who died of Covid-19 were significantly higher in comparison with surviving patients (P<0.017 and P<0.001 respectively). We also found that the HADS score was positively correlated with serum cortisol levels (r= 0.842, P=0.004). Conclusion: Our findings showed that stress and anxiety are associated with patients’ outcomes. Psychological interventions can improve the mental health of vulnerable groups during the COVID-19 epidemic. }, URL = {http://bcn.iums.ac.ir/article-1-1771-en.html}, eprint = {http://bcn.iums.ac.ir/article-1-1771-en.pdf}, journal = {Basic and Clinical Neuroscience Journal}, doi = {10.32598/bcn.11.covid19.1168.2}, year = {2020} }