TY - JOUR T1 - The Effect of TGF-alpha on Neurogenesis in Subventricular Zone of Rat Brain after Ischemia-Reperfusion TT - JF - BCN JO - BCN VL - 3 IS - 2 UR - http://bcn.iums.ac.ir/article-1-208-en.html Y1 - 2012 SP - 12 EP - 15 KW - Hippocampus KW - Ischemia KW - Subventricular Zone KW - TGF-Alpha N2 - Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After induction of ischemia-reperfusions, PBS (phosphate buffer salin) and TGF-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. After 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method. Results: Our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p M3 ER -