TY - JOUR T1 - Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease TT - JF - BCN JO - BCN VL - 3 IS - 1 UR - http://bcn.iums.ac.ir/article-1-206-en.html Y1 - 2011 SP - 48 EP - 57 KW - Aβ(25–35) KW - Varenicline KW - Passive Avoidance KW - Y Maze KW - Radial Maze KW - Rat N2 - Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an agonist of nicotinic cholinergic receptors, varenicline(0.5 and 2 μg/μl), on learning and memory impairments induced by intrahippocampal Aβ(25–35) injection was assessed in rats. Results: The results showed that the intrahippocampal Aβ(25–35) injected rats exhibit lower spontaneous alternation score inY-maze tasks (p M3 ER -