%0 Journal Article %A Soleimani Asl, Sara %A Falahati, Peiman %A shekar riz, Nima %A Molavi, Nima %A Esmaeili, Farzaneh %A Azimi, Zahra %A Sajadi, Freidoon %A Hayat, Parisa %A Samzadeh-Kermani, Alireza %A Mehdizadeh, Mehdi %T Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats %J Basic and Clinical Neuroscience Journal %V 3 %N 1 %U http://bcn.iums.ac.ir/article-1-198-en.html %R %D 2011 %K Apoptosis, N-Methyl-3, 4-Methylenedioxyamphetamine, Acetylcysteine, %X Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. %> http://bcn.iums.ac.ir/article-1-198-en.pdf %P 44-47 %& 44 %! %9 Original %L A-10-1-90 %+ %G eng %@ 2008-126X %[ 2011