AU - Khalili, Mohsen TI - The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 1 VI - 1 IP - 1 4099 - http://bcn.iums.ac.ir/article-1-12-en.html 4100 - http://bcn.iums.ac.ir/article-1-12-en.pdf SO - BCN 1 AB  -   Abstract  Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months.  Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p CP - IRAN IN - School of Medicine, Shahed university, Tehran LG - eng PB - BCN PG - 29 PT - Original YR - 2009