TY - JOUR T1 - The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats TT - JF - BCN JO - BCN VL - 2 IS - 3 UR - http://bcn.iums.ac.ir/article-1-146-en.html Y1 - 2011 SP - 51 EP - 57 KW - Quercetin KW - Diabetes Mellitus KW - Antinociception KW - Formalin Test KW - Hot Tail Immersion Test KW - Oxidative Stressof N2 - Introduction: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods: Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests. Meanwhile, some markers of oxidative stress were also measured in brain tissue.Results: Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p M3 ER -