%0 Journal Article %A Kaka, Gholamreza %A Rahmanzade, Ramin %A Safee, Farzin %A Haghparast, Abbas %T Naloxone Induces Frequent Jumping after Chronic Morphine and Methamphetamine Co-Administration in Rats %J Basic and Clinical Neuroscience Journal %V 5 %N 1 %U http://bcn.iums.ac.ir/article-1-467-en.html %R %D 2014 %K Polydrug Use, Morphine, Meth, Naloxone, Withdrawal Syndrome, Rat, %X Combined use of an opioid with a psychostimulant is popular among drug abusers. Such “polydrug use” may increase drug effects or attenuate adverse effects of either drug alone. We proposed that a combination of methamphetamine (meth) and morphine may change physical opioid withdrawal symptoms. Adult male rats were chronically injected with cumulative subcutaneous (s.c.) doses of morphine, meth or a combination of both drugs within five days. On day six, a challenge dose of the same drug was injected. Two hours later, precipitated withdrawal symptoms were scored within 30 minutes after naloxone (1mg/kg, i.p.) injection. Both frequency and incidence of jumping significantly increased in combined treated animals (P %> http://bcn.iums.ac.ir/article-1-467-en.pdf %P 42-47 %& 42 %! %9 Original %L A-10-1-194 %+ Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. %G eng %@ 2008-126X %[ 2014