@ARTICLE{Haghparast, author = {Kaka, Gholamreza and Rahmanzade, Ramin and Safee, Farzin and Haghparast, Abbas and }, title = {Naloxone Induces Frequent Jumping after Chronic Morphine and Methamphetamine Co-Administration in Rats}, volume = {5}, number = {1}, abstract ={Combined use of an opioid with a psychostimulant is popular among drug abusers. Such “polydrug use” may increase drug effects or attenuate adverse effects of either drug alone. We proposed that a combination of methamphetamine (meth) and morphine may change physical opioid withdrawal symptoms. Adult male rats were chronically injected with cumulative subcutaneous (s.c.) doses of morphine, meth or a combination of both drugs within five days. On day six, a challenge dose of the same drug was injected. Two hours later, precipitated withdrawal symptoms were scored within 30 minutes after naloxone (1mg/kg, i.p.) injection. Both frequency and incidence of jumping significantly increased in combined treated animals (P }, URL = {http://bcn.iums.ac.ir/article-1-467-en.html}, eprint = {http://bcn.iums.ac.ir/article-1-467-en.pdf}, journal = {Basic and Clinical Neuroscience Journal}, doi = {}, year = {2014} }