TY - JOUR JF - BCN JO - BCN VL - 4 IS - 4 PY - 2013 Y1 - 2013/11/01 TI - Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment TT - N2 - Introduction: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. Methods: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. Results: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p SP - 329 EP - 333 AU - Soleimani Asl, Sara AU - Pourheydar, Bagher AU - Dabaghian, Fataneh AU - Nezhadi, Akram AU - Roointan, Amir AU - Mehdizadeh, Mehdi AD - KW - Apoptosis KW - Ginger KW - MDMA KW - Caspase UR - http://bcn.iums.ac.ir/article-1-437-en.html ER -