RT - Journal Article T1 - The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics JF - BCN YR - 2013 JO - BCN VO - 4 IS - 1 UR - http://bcn.iums.ac.ir/article-1-310-en.html SP - 31 EP - 35 K1 - Ciprofloxacin K1 - Absence epilepsy K1 - Wag/Rij K1 - EEG AB -  Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and .nd new effective substance against this kind of epilepsy. LA eng UL http://bcn.iums.ac.ir/article-1-310-en.html M3 ER -