AU - Hosseini, Mahmoud AU - Pourganji, Masoume AU - Khodabandehloo, Fatimeh AU - Soukhtanloo, Mohammad AU - Zabihi, Hoda TI - Protective Effect of L-Arginine against Oxidative Damage as a Possible Mechanism of its Bene.cial Properties on Spatial Learning in Ovariectomized Rats PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 3 VI - 5 IP - 5 4099 - http://bcn.iums.ac.ir/article-1-281-en.html 4100 - http://bcn.iums.ac.ir/article-1-281-en.pdf SO - BCN 5 AB  - Introduction: The role of ovarian hormones and nitric oxide (NO) on oxidative damage in brain tissues as well as learning and memory has been widely investigated.The present study was carried out to evaluate the effect of the precursor of NO, L-Arginine on learning and brain damage due to oxidative stress in ovariectomized (OVX) rats.Methods: Thirty -two rats were divided into four groups: 1) Sham, 2) OVX, 3) Sham-L-Arginine (Sham-LA) and 4) OVX-L-Arginine(OVX-LA).  The animals of sham- LA and OVX-LA were treated with 500 mg/kg of L-Arginine. The animals in Sham and OVX groups received 1 ml/kg saline. The animals were tested in Morris water maze and .nally, the brains were removed and MDA and total thiol concentrations were measured.Results: The escape latency and swimming path in OVX group were signi.cantly higher than in Sham group (p CP - IRAN IN - LG - eng PB - BCN PG - 36 PT - Original YR - 2012