TY - JOUR JF - BCN JO - BCN VL - 3 IS - 4 PY - 2012 Y1 - 2012/8/01 TI - Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult Rats TT - N2 - Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences were observed among females. In addition, no significant behavioral alterations between male and female animals were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavioral abnormalities in adults. SP - 60 EP - 67 AU - Moghadami, Malihe AU - Moghimi, Ali AU - Ahangar, Emad AU - Jalal, Razieh AU - Rassouli, Morteza Behnam AU - Mahdavi Shahri, Naser AD - KW - Anxiety KW - Elevated plus maze KW - Exploratory KW - Hyperglycemia KW - Locomotive KW - Open field. UR - http://bcn.iums.ac.ir/article-1-256-en.html ER -