%0 Journal Article %A Jaberzadeh, Shapour %A Bastani, Andisheh %A Kidgell, Dawson %T Does the Longer Application of Anodal-Transcranial Direct Current Stimulation Increase Corticomotor Excitability Further? A Pilot Study %J Basic and Clinical Neuroscience Journal %V 3 %N 4 %U http://bcn.iums.ac.ir/article-1-251-en.html %R %D 2012 %K Ttranscranial Ddirect Ccurrent Sstimulation, tDCS, Ttranscranial Mmagnetic Sstimulation, TMS, Ccorticomotor Eexcitability, %X  Introduction: Anodal transcranial direct current stimulation (a-tDCS) of the primary motor cortex (M1) has been shown to be effective in increasing corticomotor excitability.  Methods: We investigated whether longer applications of a-tDCS coincide with greater increases in corticomotor excitability compared to shorter application of a-tDCS. Ten right-handed healthy participants received one session of a-tDCS (1mA current) with shorter (10 min) and longer (10+10 min) stimulation durations applied to the left M1 of extensor carpi radialis muscle (ECR). Corticomotor excitability following application of a-tDCS was assessed at rest with transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEP) and compared with baseline data for each participant.  Results: MEP amplitudes were increased following 10 min of a-tDCS by 67% (p = 0.001) with a further increase (32%) after the second 10 min of a-tDCS (p = 0.005). MEP amplitudes remained elevated at 15 min post stimulation compared to baseline values by 65% (p = 0.02).  Discussion: The results demonstrate that longer application of a-tDCS within the recommended safety limits, increases corticomotor excitability with after effects of up to 15 minutes post stimulation. %> http://bcn.iums.ac.ir/article-1-251-en.pdf %P 28-35 %& 28 %! %9 Original %L A-10-1-117 %+ %G eng %@ 2008-126X %[ 2012